Renal impairment. The pharmacokinetics of dapoxetine 60 mg in combination with tadalafil 20 mg and sildenafil mg were evaluated in a single dose crossover study C If you are due to have an operation or any dental treatment, please tell the person carrying out the treatment which medicines you are taking. PDE5 inhibitors. Priligy should be prescribed with caution in patients taking medicinal products with vasodilatation properties such as alpha adrenergic receptor antagonists, nitrates due to possible reduced orthostatic tolerance see Section 4. Priligy is only indicated in men with PE who meet all the criteria listed, see Section 4. If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.PRILIGY contains the active ingredient dapoxetine and is a type of drug called a selective serotonin reuptake inhibitor (SSRI) and it is also known as a urological medicine. PRILIGY increases your time to ejaculation and can improve your control over ejaculation and reduce your distress over how fast you ejaculate. PRILIGY contains the active ingredient dapoxetine and is a type of drug called a selective serotonin reuptake inhibitor (SSRI) and it is also known as a urological medicine. PRILIGY increases your time to ejaculation and can improve your control over ejaculation and reduce your distress over how fast you ejaculate. Priligy is a prescription-only medicine to help treat symptoms of premature ejaculation (PE), in men aged between 18 and It contains dapoxetine, a ‘short-acting selective serotonin reuptake inhibitor’ (SSRI). Priligy was the first oral treatment for PE to be licensed in the UK.