That means eating healthy foods, exercising, getting good sleep, limiting stress, and treating other health conditions that might cause ED, like high blood pressure, heart disease, diabetes, obesity, and low testosterone, Dr. But, keep in mind that ED might signal an underlying medical problem, like high blood pressure, heart disease, diabetes, low testosterone, or sleep apnea. Risks While Vitaros alprostadil cream is generally well-tolerated, a study did report users experiencing mild, short-lived side effects, including genital pain, tenderness, and skin redness. It contains the ingredient alprostadil, a natural prostaglandin. These medicated creams are applied topically to the penis prior to sex.The Food and Drug Administration just granted over-the-counter sale marketing authorization for MED, a topical gel created to treat erectile dysfunction (ED). Viagra is a phosphodiesterase inhibitor that works to prevent PDE5, which limits blood flow to the penis. The result of using Viagra can be a stronger erection. How do you apply nitroglycerin. Instead, it’s a gel that can be placed directly onto your penis to help achieve an erection. And on top of that, you won’t need a prescription to get Eroxon as it will be available.