However, daily use of sertraline may cause unwanted and prolonged side effects, 8 , 9 , 10 such as dizziness, nausea, headache, diarrhea, and fatigue, and, given its off-label nature, the use of sertraline for the treatment of PE is considered risky in China. Think back on your relationships and sexual encounters since you became sexually active. Basic questions to ask your doctor The list below suggests questions to ask your health care provider about premature ejaculation. These condoms contain numbing agents such as benzocaine or lidocaine to delay ejaculation. By repeating as many times as needed, you can reach the point of entering your partner without ejaculating. These medications usually take 5 to 10 days to begin working. Due to the intimate nature of the problem, most patients hesitate to seek treatment.At present, dapoxetine is licensed in ten countries, including several countries in Europe, and Mexico, South Korea, and New Zealand. 1, 2 PE is the most common sexual . Dapoxetine. Star 2. Summary. Dapoxetine is a selective serotonin reuptake inhibitor used in the treatment of premature ejaculation. Generic Name. Dapoxetine. DrugBank . Dapoxetine is being developed by J&J’s drug delivery subsidiary Alza and Pharmaceutical Product Development. If approved by the FDA, it will be marketed in the USA by J&J’s .