More serious side effects may include a drop in blood pressure or an erection that lasts longer than four hours. Independent online pharmacies operate solely on the Internet, either domestically or internationally. Finding an online ED provider can feel overwhelming. Those with pre-existing conditions should always consult a healthcare provider before taking new medications or supplements. The mechanism of action for ED pills is simple: They inhibit the PDE5 enzyme which regulates the signals responsible for the smooth muscle tissue.$ Get free savings. Online Pharmacy & OTC Our 12 Picks for Online Pharmacies of If you need medication delivered here are the best online pharmacies—and how to choose the right one for you By Natalie Rahhal Updated on April 21, Medically reviewed by Chris Vincent, MD Fact checked by James Lacy Print. Generic Viagra (sildenafil) is an alternative to the branded Viagra drug that can be used for treating erectile dysfunction (ED). It’s now sold by many manufacturers, including online.

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