In our latest question and answer, we discuss whether or not generic Cialis Tadalafil is as effective as the brand as well as dosing information. You can take this medicine with or without food 30 minutes before sex, depending on the dose. It lasts 4 to 5 hours, or longer if you have mild to moderate ED. Side effects Side effects of oral ED medicines are often mild. Over a weekend away, that would mean potentially as little as 30 minutes of waiting time for a stronger erection.Is generic Cialis or tadalafil as effective as Cialis? Cialis and tadalafil are equally effective. The FDA works to ensure that the generic versions of all brand-name . Is generic tadalafil any different from brand-name Cialis? No. Both tadalafil and Cialis are used to treat erectile dysfunction and benign prostatic . If a pharmacy, or someone in the United States is offering generic Cialis (tadalafil), be very wary as there is a good chance it is fraudulent. If you are getting it .